Exposure on the glucuronide metabolite is 35 to 40 times increased than publicity on the mum or dad drug. In vitro data propose that hydromorphone in clinically suitable concentrations has nominal potential to inhibit the action of human hepatic CYP450 enzymes which include CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.There might be new information and fa